为什么偏偏是我得偏头痛？ - 偏头痛社区

<p style="margin-top: 0px; margin-bottom: 24px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; font-size: 17px; letter-spacing: 0.544px; text-align: left; white-space: normal; text-size-adjust: auto; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 2em;">虽然偏头痛的潜在病因至今仍然不能明确。但可以明确的是：偏头痛可能与一系列环境和遗传因素相关。偏头痛患者在诱因敏感性程度上表现的差异，应该与遗传因素有很大关系。 <p style="margin-top: 0px; margin-bottom: 24px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; font-size: 17px; letter-spacing: 0.544px; white-space: normal; text-size-adjust: auto; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 2em; text-align: left;">早期对于偏头痛遗传机制的研究是通过家族性偏瘫型偏头痛（familial hemiplegic migraine, FHM）进行的，这是一种罕见的符合孟德尔遗传定律的具有先兆症状的偏头痛。家族性偏瘫性偏头痛是单基因疾病，已确定的缺陷基因为CACNA1A、ATP1A2和SCNA1A。这三种FHM相关基因均参与离子通道转运，细胞及动物实验表明，神经元超兴奋是FHM头痛及先兆症状的一种潜在细胞机制。FHM的主要症状头痛、先兆症状伴随恶心、畏光、声音恐惧症与先兆偏头痛症状类似，表明FHM相关基因或编码其他金属离子通道基因确实与偏头痛相关。<p style="margin-top: 0px; margin-bottom: 24px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; font-size: 17px; letter-spacing: 0.544px; text-align: left; white-space: normal; text-size-adjust: auto; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 2em;">在过去的几年，证实与偏头疼相关的风险基因位点显著增加（2016年IHGC GWAS中发现了44个遗传风险基因位点）。随后有研究致力于发现致病基因，研究发现多种不同通路异常，包括血管通路、电解质稳态及神经元迁移等等。<img data-croporisrc="https://mmbiz.qpic.cn/mmbiz_png/lA4qYwHXtg8Sb7OTibSeFghhweRaiaPTI8UfWp68rEp3fqBasDW9alia9nupYojIYsB7p45ubUka8HroQleABOchw/0?wx_fmt=png" data-cropx1="0" data-cropx2="674" data-cropy1="116.8162662622715" data-cropy2="852.4117647058822" data-galleryid="" data-ratio="1.0919881305637982" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_jpg/lA4qYwHXtg8Sb7OTibSeFghhweRaiaPTI8ic7hZSzicNhIECeFE4xFGiciabYRUQa2wq1MaWSZxVeibJpk9gJaRlI4AJg/640?wx_fmt=jpeg" data-type="jpeg" data-w="674" data-index="1" src="/uploads/ueditor/20230316/6412975a52fb9.png" _width="578px" crossorigin="anonymous" alt="图片" data-fail="0" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; vertical-align: bottom; height: auto !important; visibility: visible !important; width: 578px !important;"/><p style="margin-top: 0px; margin-bottom: 24px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; font-size: 17px; letter-spacing: 0.544px; text-align: left; white-space: normal; text-size-adjust: auto; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 2em;">偏头痛会有多大的概率会遗传给孩子？根据美国头协会发布的统计数据：<p style="margin-top: 0px; margin-bottom: 24px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; font-size: 17px; letter-spacing: 0.544px; text-align: left; white-space: normal; text-size-adjust: auto; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 2em;">1、如果父母双方中有一人患有偏头痛，孩子有50%的机率会患有偏头痛；<p style="margin-top: 0px; margin-bottom: 24px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; font-size: 17px; letter-spacing: 0.544px; text-align: left; white-space: normal; text-size-adjust: auto; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 2em;">2、如果父母双方都患有偏头痛，那么孩子患偏头痛的机率就有75%；<p style="margin-top: 0px; margin-bottom: 24px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; font-size: 17px; letter-spacing: 0.544px; text-align: left; white-space: normal; text-size-adjust: auto; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 2em;">3、女孩被遗传到偏头痛的概率是男孩的2-3倍。<p style="margin-top: 0px; margin-bottom: 24px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; caret-color: rgb(34, 34, 34); color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif; font-size: 17px; letter-spacing: 0.544px; text-align: left; white-space: normal; text-size-adjust: auto; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 2em;">这是美国头痛协会发布的数据，并不一定会适合我国的情况，但是无论如何，如果你有偏头痛，那么一定要多关心一下自己孩子的情况。